Gene Testing Cracks Code for Drug-Metabolizing Effects

Genetic tests today are so advanced they provide biological clues related to medical risk factors and personality traits. Although there is no absolute evidence that gene testing predicts you will develop a certain mental disorder, pharmacogenomics tests do shed light on whether a specific medication could assist with an existing psychiatric diagnosis.

Gene Testing Cracks Code for Drug-Metabolizing Effects

How does gene testing help?

Pharmacogenomic tests zero in on genetic variants that tell professionals about how your body metabolizes or processes various drugs. Such key information leads to more helpful dosing because everyone’s body responds differently to specific drugs. For example, genetic and psychological factors contribute to antidepressant side effects reported by individuals.

Researchers say some of the most prevalent pharmacogenetics tests include CYP2C19 as well as CPY2D6 and CPY2C9. Depending on a person’s “CYP phenotypes,” a prescriber works to find the optimal starting dose and type of antidepressant medication. In fact, prescribers often use genetically informed guidelines.

Which drugs are not tolerated by everyone?

CYP2D2 is the enzyme identified as influencing the metabolism of various opiates, including oxycodone, codeine, hydrocodone and tramadol. CYP2C19 is associated with the metabolism of carisoprodol, diazepam, clopidogrel and several antidepressants. Meanwhile, CYP2CD is the enzyme credited with metabolizing NSAIDs or nonsteroidal anti-inflammatory drugs.

If you have had past trouble tolerating a certain antidepressant or other medication, consider gene testing. Your prior conditioning, anxiety and expectations based on preconceived ideas could influence drug tolerability, so it’s important to work with trained professionals who understand drug tolerability, genetic influences and neuroticism.

Should I obsess over my genes?

When it comes to a treatment plan – particularly more complicated concurrent therapies — understanding drug interactions is paramount to achieving safe and effective outcomes. Avoid adverse consequences with proper gene testing. At the same time, relax knowing we have scientific-based guidelines and treatment solutions. Although it’s tempting to analyze your specific genes for personality, mental health and physical health risks, ultimately your power is in mental health resources and support.

At Pandora’s House Psychiatry, we specialize in psychiatric mental health solutions for adults, adolescents and children. Talk to us about our at-home telemedicine and telehealth options for those who desire proven methods for coping and improving their quality of life. Improving mental health often means boosting life span and productivity as well as increasing the sense of self-worth. For more information about treating anxiety disorders, bipolar related disorders, substance abuse, gene testing and more, please contact us today.